急性心肌梗死患者CK-MB、cTnI和cTnT的动态变化及其联合检测的诊断价值

Combination detection of CK-MB,cTnI and cTnT in the early diagnosis of acute myocardial infarction

目的探讨肌酸激酶同工酶(CK-MB)、心肌肌钙蛋白I(cTnI)和心肌肌钙蛋白T(cTnT)在急性心肌梗死(AMI)早期的动态变化及其联合检测的诊断价值。方法将因急性胸痛发作就诊的患者分为AMI组(70例)和非AMI组(66)例,在发病后不同时间点检测并比较CK-MB、cTnI和cTnT水平。结果胸痛发作后≤3h、>3～6h、>6～12h、>12～24h和>24～48hAMI组CK-MB、cTnI和cTnT水平均高于非AMI组,差异有统计学意义(P<0.05);3项指标联合检测诊断AMI的灵敏度和特异度分别为97.14%和90.91%,均高于单独检测。结论联合检测CK-MB、cTnI和cTnT可明显提高AMI早期诊断的灵敏度和特异度。

Objective To explore the clinical significance of Creatine kinase MB（CK-MB）,cardiac troponin I（cTnI） and cardiac troponin T（cTnT） in the early diagnosis of acute myocardial infarction（AMI）.Methods One hundred and thirty-six patients with acute chest pain were involved in this study.Venous blood was collected from each patient at different time to detect CK-MB,cTnI and cTnT.All patients were divided into AMI group（n=70） and non-AMI group（n=66）,and their detection results of CK-MB,cTnI and cTnT were compared.Results All of the levels of CK-MB,cTnI and cTnT on ≤3 h,3～6 h,6～12 h,12～24 h and 24～48 h after chest pain were higher in AMI group than those in non AMI group（P0.05）.The combination detection of sensitivity and specificity for acute myocardial infarction with CK-MB,cTnI and cTnT were 97.14% and 90.91% respectively,which were higher than those detected single.Conclusion The combination detection of CK-MB,cTnI and cTnT can improve sensitivity and specificity of diagnosis of acute myocardial infarction,which are in accordance with the diagnosis of coronary arteriongraphy.