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抗生素致肠道菌群失调性腹泻患儿血清C反应蛋白的变化及其临床意义 被引量：5

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摘要 目的探讨抗生素致肠道菌群失调性腹泻患儿血清C反应蛋白(CRP)的变化及其临床意义,并分析其临床特点。方法分析97例肠道菌群失调性腹泻患儿的临床资料,并采用酶联免疫法(ELISA)检测97例患儿和22名健康对照组儿童血清中CRP的变化。结果 97例肠道菌群失调性腹泻患儿均使用过抗菌药物,主要是第3代头孢菌素和2种或以上抗生素联合使用(占71.13%)。患儿感染的细菌以链球菌居多(占77.32%);肠道菌群失调性腹泻患儿血清中CRP的表达显著高于对照组(P<0.01);血清CRP的表达与患儿性别、年龄和抗生素使用情况无关(P>0.05)。结论小儿肠道菌群失调性腹泻主要危险因素是使用广谱抗菌药物,临床医生应重视早期病原学检查;同时,检测肠道菌群失调性腹泻患儿血清CRP的水平,对临床诊断和治疗具有重要意义。
作者 金忠芹 武庆斌 唐伟国
机构地区 苏州大学附属儿童医院消化科
出处 《苏州大学学报（医学版）》 CAS 北大核心 2011年第6期1014-1016,共3页 Suzhou University Journal of Medical Science
关键词 肠道菌群失调 腹泻 抗生素 C反应蛋白
分类号 R725.7 [医药卫生—儿科]
  • 相关文献

参考文献9

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共引文献5

同被引文献28

引证文献5

二级引证文献42

苏州大学学报（医学版）
2011年 第6期

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