经动脉灌注化疗治疗癌性腹水的临床观察

Clinical Observation on the Treatment for Malignant Ascite by Transcatheter Arterial Perfusion Chemotherapy

目的:探讨经动脉灌注化疗治疗癌性腹水的疗效。方法:晚期胃肠恶性肿瘤发生转移性癌性腹水的患者32例,用Seldinger方法,选择腹腔动脉、肠系膜上动脉、肠系膜下动脉注入化疗药物奥沙利铂150 mg,5氟尿嘧啶(5-Fu)500 mg。治疗后测量腹围,并行B超检查腹腔积液量,疗程为每月1次,2个疗程后评价疗效。结果:完全缓解(CR)2例(6.25%),部分缓解(PR)15例(46.8%),无变化(NC)10例(31.2%),病情进展(PD)5例(15.6%),总有效率(CR+PR)为53.05%。结论:经动脉灌注化疗治疗癌性腹水近期疗效确切,不良反应轻,且能显著改善患者的生活质量,是晚期肿瘤综合治疗中一项重要的治疗方法。

Objective：To observe the effects of the treatment for malignant ascite by transcatheter arterial perfusion chemotherapy. Methods：A total of 32 patients suffered intraperitoneal fluid caused by later period stomach and intestines malignant tumor,the routine use of a Seldinger method,select corresponding artery treating chemotherapy medicine.Chemotherapy scheme：Oxaliplatin 150mg,5-Fu 500mg.Monthly once,post treatment measure the abdomen encirclement,inspect the amount of intraperitoneal fluid by B scan,assess the cures effect at 2 months post treatment.Results：After the treatment,the intraperitoneal fluid has inordinately fading in most paients[complete response（CR） 6.25%,partial response（PR） 46.8%,no change （NO 31.2%,progressive disease（PD） 15.6%,CR ＋ PR 53.05%）].Conclusions：The short-term efficacy of the treatment for malignant ascite by transcatheter arterial perfusion chemotherapy is definite and lessside effects.it can improve the sufferer s living mass obviously,it should be an important treatment of the combined treatment for advanced cancer.