右旋美托嘧啶对术中镇静药量和术后谵妄的影响

Impact of Dexmedetomidine on Intraoperative Sedative Consumption and Postoperative Delirium

目的:探讨右旋美托嘧啶(dexmedetomidine,DEX)对术中镇静药用量和术后谵妄的影响。方法:全麻下行结直肠癌根治术的患者80例随机分为2组:(1)DEX组(D组,n=40)术前10 min内静脉输注右旋美托嘧啶0.7μg/kg并以0.4μg/(kg·h)持续输注至术毕;(2)对照组(C组,n=40)以0.9%氯化钠液代替DEX,用法、用量与D组相同。观察记录2组患者的心率、血压、脉搏氧饱和度、状态熵、术中丙泊酚用量、术后谵妄分级量表评分和Ramsay镇静评分。结果:D组患者丙泊酚用量比C组患者显著减少(P<0.05),D组患者术后谵妄分级量表评分和Ramsay镇静评分均比C组患者显著降低(P<0.05)。结论:DEX可减少术中丙泊酚用量,减少术后谵妄的发生率。

Objective：To observe the beneficial effects of dexmedetomidine on intraoperative propofol consumption and the incidence of postoperative delirium in patients receiving general anesthesia.Methods：A total of 80 patients（ASA ClassⅠ～Ⅱ） scheduled to receive colorectal cancer surgery under general anesthesia were randomly divided into 2 groups：dexmedetomidine group（Group D） or control group（Group C）.Group D：patients were given a loading dosage of dexmedetomidine（O.7 fig/kg） intravenously 10mins before the induction of general anesthesia followed by continuous infusion（0.4μg/kg？h）.Goup C：patients were given 0.9%saline solution instead of dexmedetomidine.Intraoperative propofol consumption,delirium rating scale and Ramsay sedation score were documented.Results：Compared with patients in Group C,patients in Group D had lower delirium rating scale and Ramsay sedation score and propofol consumption（P〈0.05）.Conclusions：Dexmedetomidine may decrease intraoperative sedative consumption and prevent postoperative delirium in patients receiving general anesthesia.