肺癌患者手术前后血清NSE、CYFRA21-1、CEA的变化及临床意义

Changes of serum NSE,CYFRA21-1 and CEA in patients with lung cancer before after operation and related clinical significance analysis

目的探讨血清神经元烯醇化酶(NSE)、细胞角蛋白19片段(CYFRA21-1)及癌胚抗原(CEA)在肺癌患者手术前后的水平变化及临床意义。方法选择肺癌患者105例,肺良性病变患者54例。采用电化学发光法检测了手术前后血清NSE、CYFRA21-1、CEA水平。结果肺癌组血清NSE和CYFRA21-1、CEA水平高于胃良性疾病组,差异有统计学意义(P<0.01)。肺癌患者行根治性手术组术后血清NSE、CYFRA21-1、CEA水平明显低于手术前,差异有统计学意义(P<0.01)。结论手术切除肿瘤特别是行根治性切除术后,血清NSE、CYFRA21-1、CEA水平显著降低,动态观察NSE、CYFRA21-1、CEA水平及其变化,对肺癌的辅助诊断、预后判断有重要的价值。

Objective To explore the changes of serum neuron specific enolase（NSE）,cytokeratin 19 fragment（CYFRA21-1） and carcinoembryonic antigen（CEA） in patients with lung cancer before and after operation and related clinical significance.Methods Electrochemiluminescene analyzer was used to detect the content of serum NSE,CYFRA21-1 and CEA in 105 patients with lung cancer（cancer group） and 47 control patients with benign lung diseases（benign diseases group）.Results The contents of NSE,CYFRA21-1 and CEA in cancer group were higher than those in benign diseases group（P0.01）,and in cancer group,detected results of the three indexes were significantly decreased after radical surgery（P0.01）.Conclusion Radical resection could reduce the content of NSE,CYFRA21-1 and CEA in patients with lung cancer.To dynamically determine serum level of NSE,CYFRA21-1 and CEA might be very useful for the auxiliary diagnosis and prognosis of lung cancer.