脂蛋白相关磷脂酶A2与急性缺血性脑卒中的相关性研究

Correlation study about lipoprotein associated lipoprotein phospholipase A2 and acute ischemic strokes

目的通过检测急性缺血性脑卒中患者血浆脂蛋白相关磷脂酶A2(Lp-PLA2)浓度,探讨两者的关系,为临床诊断、治疗提供依据。方法选择急性缺血性脑卒中患者(151例)为研究对象,未卒中患者(100例)作对照,血浆Lp-PLA2检测采用酶联免疫吸附法(ELISA)。结果 (1)急性缺血性脑卒中组血浆Lp-PLA2浓度高于对照组,差异有统计学意义(t=21.307,P=0.000)。血浆Lp-PLA2浓度与急性缺血性脑卒中的风险呈正相关。(2)各型急性缺血性脑卒中血浆Lp-PLA2浓度差异均无统计学意义(P>0.05)。结论 Lp-PLA2是急性缺血性脑卒中的危险标志物,测定Lp-PLA2浓度有助于制定预防策略,为急性缺血性脑卒中的预防及临床治疗提供依据。

Objective To explore the relationship between plasma level of lipoprotein associated phospholipase A2（Lp-PLA2） and acute cerebral arterial thrombosis（ACAT） to provide the basis for clinical diagnosis and therapy of disease.Methods Enzyme-linked immunosorbent assay（ELISA） was performed for the detection of plasma level of Lp-PLA2 in 151 cases of patients with ACAT （experimental group） and 100 cases of healthy controls（control group）.Results （1） Plasma level of Lp-PLA2 in experimental group were higher than control group（t=21.307,P=0.000）.There were positive correlations between plasma Lp-PLA2 level and the risks factors of ACAT.（2）There was no difference of plasma Lp-PLA2 level between patients with different types of ACAT （P0.05）.Conclusion Lp-PLA2 could be a risk marker for ACAT and detection of its plasma level might be helpful for guiding prevention strategies and providing basis for clinical therapy.