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持续气道正压通气对阻塞性睡眠呼吸暂停低通气综合征患者肺动脉压力及右室前壁厚度的影响

Effects of CPAP for right ventricular anterior wall thickness and pulmonary arterial pressure in patients with obstructive sleep apnea-hyponea syndrome
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摘要 目的观察持续气道正压通气(continuous positive airway pressure,CPAP)治疗前后阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea-hypopnea syndrome,OSAHS)患者肺动脉压力和右室前壁厚度的变化。方法确诊为OSAHS的患者,根据心脏彩超检查结果,分为轻度肺动脉高压组、中重度肺动脉高压组和肺源性心脏病组。观察经CPAP治疗前,治疗1个月、3个月肺动脉收缩压和右室前壁厚度的变化。结果①肺动脉高压患者治疗1个月和治疗前相比,肺动脉收缩压差异无统计学意义(P〉0.05);呼吸暂停低通气指数(apnea-hypopnea index,AHI)及平均经皮血氧饱和度(percutaneous oxygen saturation,SpO2)差异有统计学意义(P〈0.05);治疗3个月和治疗前相比,肺动脉收缩压、AHI及平均SpO2差异有统计学意义(P〈0.05)。②肺源性心脏病患者治疗1个月和治疗前相比,肺动脉收缩压、右室前壁厚度差异无统计学意义(P〉0.05);治疗3个月和治疗前相比,肺动脉收缩压、右室前壁厚度差异有统计学意义(P〈0.05)。结论对于合并肺动脉高压和(或)肺源性心脏病的OSAHS患者,CPAP是降低其肺动脉压力、改善右心结构的有效手段。 Objective To observe the changes of right ventricular anterior wall thickness and pulmonary artery pressure before and after CPAP treatment in patients with OSAHS. Methods According to eehoeardiography findings, patients were divided into mild, moderate-severe pulmonary hypertension group and cor pulmonale group, observe the changes of right ventricular anterior wall thickness and pulmonary artery pressure in patients with OSAHS after CPAP treatment 1 month and 3 months. Results 1Apnea hyponea index and average SpO2 have changed after 1 month and 3 months in the patients with pulmonary hypertension ( P 〈 0.05), but pulmonary artery systolic pressure have changed after 3 months in the patients with pulmonary hypertension ( P 〉 0.05). 2 Pulmonary artery systolic pressure and right ventricular anterior wail thickness have no significant improved after CPAP treatment 1 month in patients with cor pulmonale ( P 〉0.05), but have significant improved after CPAP treatment 3 months ( P 〈0.05). Conclusions CPAP is an effective treatment in patients with OSAHS, that can reduced pulmonary artery systolic pressure and improved right heart structure.
出处 《国际呼吸杂志》 2012年第3期197-200,共4页 International Journal of Respiration
关键词 阻塞性睡眠呼吸暂停低通气综合征 肺动脉高压 持续气道正压通气 Obstructive sleep apnea-hyponea syndrome Pulmonary arterial hypertension Continuous positive airway pressure
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