血管紧张素转换酶-2在肺部疾病中的研究进展

Progress of studies on angiotensin-converting enzyme 2 in lung disease

肾素-血管紧张素系统（renin—angiotensinsystem，RAS）在维持血压和体内水盐平衡方面起重要作用。目前的研究提示RAS与肺纤维化、肺动脉高压等多种呼吸系统疾病的发病机制相关，而血管紧张素转换酶-2（angiotensin—convertingenzyme-2，ACE2）是ACE同工酶，起负向调节RAS活性的作用，对急性呼吸窘迫综合征等肺部疾病起保护作用，有望成为呼吸系统疾病治疗的新靶点。

The renin-angiotensin system （RAS） plays a central role in the maintainance of homeostasis of blood pressure and electrolyte balance. Recently, the RAS has been implicated in the pathogenesis on the pathogenesis of respiratory disease, especially in pulmonary fibrosis, pulmonary artery hypertension. Angiotensin-converting enzyme 2 was cloned as a first homolog of human ACE and functioned as an negative regulator of RAS. Recent studies has confirmed the protective effect of ACE2 against acute lung injury. In this review we shall discuss the roles for ACE2 in disease pathogenesis and the possibility of ACE2 as a novel approach for the treatment of lung diseases.