细胞微环境介导肿瘤P-糖蛋白的表达调控

Expression and regulation of P-glycoprotein mediated by cellular microenvironment in cancer

P-糖蛋白（p-gP）表达调控与肿瘤多药耐药的发生发展密切相关。肿瘤细胞面临自身微环境内源性损伤及外源性刺激伤害，这些不利的细胞微环境触发细胞应激反应，并通过激活系列信号传导通路调控P-gp的表达。研究肿瘤细胞内源性微环境与外源性刺激损伤对P—gp的表达调控将对探寻肿瘤细胞多药耐药获得具有重要意义。

Expression and regulation of the P-glycoprotein （P-gp） is associated with the development of muhidrug resistance in cancer. Cancer ceils are exposed in endogenous damages from its own micro-environ- ments and inflicted stimulated damages. These harmful micro-environments could trigger cellular stress response and regulated the expression of P-gp through various activated signal transduction pathways. Researches of the cellular endogenous micro-environments and exogenous stimulation damages on the expression and regulation of P-gp would have important significance for exploring the multidrug resistance of cancer cell.