DNA甲基化与胃癌的相关性

DNA methylation and gastric cancer

在胃癌的发展过程中常发现肿瘤相关基因的异常甲基化存在，其中包括全基因组的低甲基化和某些抑癌基因的高甲基化。另外，DNA甲基化水平似乎还与胃癌的预后密切相关。近年来为揭示DNA甲基化与胃癌的相关性进行了大量研究。

Abnormal methylation of the tumor-related genes is frequently found in the development of gastric cancer. Cancer cells exhibit two opposing methylation abnormalities： genome-wide hypomethylation and certain tumor suppressor gene hypermethylation. Furthermore, it seems that the level of DNA methylation is closely associated with the prognosis of gastric cancer. Recently, a great deal of research has been conducted to reveal the corelation of DNA methylation and gastric cancer.