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TNFα-850C/T基因多态性与Graves病的相关性

Study on TNFα-850C/T polymorphisnis in Graves disease patients
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摘要 目的探讨肿瘤坏死因子TNFα-850C/T基因多态性与毒性弥漫性甲状腺肿(Graves病)的关系。方法运用多聚酶链反应技术检测60例Graves病及119例正常人肿瘤坏死因子TNFα-850C/T基因多态性。结果 Graves病组肿瘤坏死因子TNFα-850C/C、T/C、T/T表型频率分别为:0.7167、0.2667、0.0196,对照组分别为0.7899、0.1932、0.0168;Graves病组TNFα-850T、TNFα-863C基因频率分别为:0.8500、0.1500,对照组分别为:0.8866、0.1134;TNFα-850C/T各种基因型频率在Graves病组与正常对照组之间差异无统计学意义(P>0.05)。结论肿瘤坏死因子TNFα-850C/T基因多态性与Graves病无明显相关。 Objective To investigate the relationship between tumor necrosis factor（TNF）-850C/T polymorphism and Graves.Methods the polymorphism of TNFα-850C/T gene was screened by PCR-RELP.Results the gene frequency of TNFα-850C/T in uveitis group was as followed;TNFα-850 C/C、T/C、T/T genotype frequency：0.7167、0.2667、0.019,TNFα-850 C、TNFα-850 T Gene frequency： 0.8500、0.1500.TNFα-850 C/C、T/C、T/T genotype frequency in control group was as followed： 0.7899、0.1932、0.0168,TNFα-850 C、TNFα-850 T Gene frequency：0.8866、0.1134,There were no significant differences in the frequencies of TNFα-850C/T gene between Graves patients and control group（P0.05）.Conclusion no evident association was found between TNFα-850C/T polymorphism and Graves.
作者 赖绮云 冯锦辉 陈盛强
机构地区 广州番禺区中心医院 广州市番禺区石碁人民医院 广州医学院第二附属医院
出处 《中国热带医学》 CAS 2011年第12期1442-1444,共3页 China Tropical Medicine
基金 番禺区科技项目(No.2009-z-97-1 No.2009-z-83-1)
关键词 GRAVES病 肿瘤坏死因子α-850C/T 多态性 TNFα-850C/T gene Graves disease Polymorphism
分类号 R581 [医药卫生—内分泌]
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参考文献9

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中国热带医学
2011年 第12期

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