云南大理州2002～2009年GAVI项目乙肝疫苗免疫效果

Effect of hepatitis B vaccine immunization of GAVI program in Dali Prefecture in 2002～2009

目的评价大理州卫生部/全球疫苗和免疫联盟合作项目（GAVI项目）乙型肝炎疫苗（HepB）纳入免疫规划的效果。方法采用SPSS15.0统计软件对大理州各项目县（市）常规免疫报表、GAVI项目进展报告和终期报告数据进行分析。结果大理州自2003年实施GAVI项目以来,全程接种率（HepB3）和估算接种率（HepB3/DPT3）比2002年分别提高了48.11%和60.57%;HepB1及时接种率、住院分娩及时接种率和估算及时接种率（HepB1/DPT1）比2003年分别提高到152.97%、110.85%和169.43%,差异有统计学意义（P〈0.01）。但在家出生儿童HepB1及时接种率只有28.91%。2006年调查1~3岁儿童的HBsAg阳性率为1.67%,比2003年下降42.85%;抗-HBs阳性率为66.67%,比2003上升了82.61%。结论 GAVI项目实施成效显著,已达项目指标要求,今后在保持较高接种率的基础上,应加强少数民族地区和边远山区的培训和宣传教育工作,提高家庭分娩儿童H epB1及时接种率。

Objective To evaluatde the effect of hepatitis B vaccine immunization of GAVI program in 2002-2009 in Dali Prefecture.Methoda The data of county routine immunization reports（including county-level cities）,progress reports of GAVI programs,and terminal reports were analyzed with SPSS 15.0 statistical software.Results Since commencement of implementation of GAVI programs in Dali Prefecture in 2003,the whole-course vaccination rate of hepatitis B vaccine in the newborns,the timely vaccination rate of HepB1,and the timely vaccination rate of newborns delivered in hospitals were greatly improved.The whole-course vaccination rate（HepB3）and the estimated vaccination rate（HepB3/DPT3）have been increased by 48.11% and 60.57%,compared with that of 2002;The timely vaccination rate of HepB1,the timely vaccination rate of newborns delivered in hospitals and the estimated timely vaccination rate（HepB1/DPT1）were increased by 152.97 %,110.85%,and 169.43%,showing significant.difference（P0.01）However,the timely vaccination rate in the newborns delivered at home was only 28.91%.According to the survey of 2006,the HBsAg positive rate of children in ages goup of of 1 to 3 years was 1.67%,a drop of 42.85% in comparison with that of 2003;anti-HBs positive rate was 66.67%,as drop of 82.61%,compared with that of 2003.Conclusion GAVI programs were carried out successfully and met the anticipated requirements.In the future,the HepB1 timely vaccination rate in thef newborns delivered at home should be improved based on the maintenance of high vaccination rate and through work of health education and training.