摘要
目的分析IL-6和IL-8预测感染或亚临床感染引起早产的准确性。方法以84名正常孕妇为对照组,69名早产孕妇为早产组,采集宫颈阴道黏液,检测B族溶血性链球菌(GBS)、乳酸杆菌、衣原体和淋球菌,ELISA法检测细胞因子IL-6和IL-8浓度。结果早产组孕妇的B族溶血性链球菌和淋球菌或衣原体感染率以及阴道pH均高于对照组(P<0.05,P<0.01);在早产组中,IL-6和IL-8检出率均明显高于对照组(P<0.01,P<0.05)。结论 IL-6和IL-8和早产均有着密切的联系,可以作为早产的临床检测指标,尤其是怀疑有生殖道感染的孕妇。
Objective To investigate the value of detection of interleukin 6 and 8 in diagnosis of premature delivery in women induced by infection.Methods Sixty-nine pregnants of premature delivery were enrolled with 84 subjects of normal term delivery as control.The infection rates of Hemolytic streptococci（GBS）and lactobacillus or Chlamydia/gonococcus were in Group B were higer than tjhat of the control group.The detection rates of interleukin 6（IL-6）and 8（IL-8）were also higher in thek premature delivery group was also higher than that of the controls（all P0.05）.Results The detection of GBS,Chlamydia and gonococcus was higher than the control group and the pregnants of premature delivery had a higher levels of IL-6（P0.01）and IL-8（P0.05）.Conclusion The levels of IL-6 and IL-8 are asscoiated with premature delivery and they could be applied as a predictor in premature delivery especially in those with infection.
出处
《中国热带医学》
CAS
2011年第12期1527-1528,共2页
China Tropical Medicine
