妊高征患者内皮素、一氧化氮测定的临床意义

The Clinical Significance of Determination of Plasma Endothelin, Nitric in Patients with Pregnancy lnduced Hypertension

目的 :了解内皮素、一氧化氮在妊高征发病中的作用。方法 :放射免疫分析法检测了39例妊高征患者、28例正常晚孕妇女产前及产后血浆ET的含量 ,同时采用Greiss法测定亚硝酸盐及硝酸盐以间接测定NO含量。结果 :妊高征患者产前ET较正常妊娠组明显升高 ,NO则明显下降(均 p<0.01) ,且与妊高征病情程度有一定关系 ,产后逐渐恢复正常。结论 :妊高征患者血管内皮细胞存在内分泌功能紊乱 ,ET合成释放增加 ,NO释放减少 ,以及两者反馈调控失衡在妊高征发病中具有重要意义。

Objective In order to study the role of plasma ET, NO in the cause of pregnancy induced hypertension (PIH).Methods The concentrations of plasma ET was detected by radioimmunoassay in 39 patients with PIH and 28 normal pregnant women. Meantime, plasma NO2/NO3 levels, the stable metabolic end product of NO was determined with Greiss determination. Rusults The antepartum plasma ET levels in patients with PIH were significantly higher than those in normal pregnancy (P<0.01), plasma NO levels were decreased markly (P<0.01). The score index of PIH had significant correlation with the levels of plasma ET, NO. And returned to non-pregnant status in postpartum period. Conclusion The functional changes of vessel endothelial cells in patients with PIH, and the inblance of endothelial relaxing and contracting factors might play an important part inthe pathogenesis of PIH.