新生猪缺氧缺血性脑损伤时地塞米松对甲状腺功能的影响

The effect of dexamethasone on the function of thyroid gland in piglets with hypoxic ischemic damage

目的 探讨新生猪缺氧缺血性脑损伤(hypoxicischemicbraindamage,HIBD)时地塞米松对甲状腺功能的影响。方法 在建立新生猪HIBD模型的基础上,对治疗组新生猪使用不同剂量地塞米松(5mg·kg-1·d-1和1mg·kg-1·d-1)共3天,分别于第24小时,第48小时及第72小时采股静脉血收集血清,以放射免疫法(radioimmunoassay,RIA)测定其游离T3(FT3)和游离T4(FT4)浓度。结果 HIBD新生猪FT3、FT4水平较正常对照组降低,其中第48小时差异有显著性(P<005);治疗组FT3、FT4浓度均较HIBD组有所增高。结论 应用地塞米松似能促进或改善HIBD新生猪的甲状腺分泌功能。临床新生儿缺氧缺血性脑病(hypoxicischemicencephalolpathy,HIE)时以使用较小剂量地塞米松为宜。

Objective To investigate the effects of dexamethasone on the function of thyroid gland in piglets with hypoxic ischemic brain damage(HIBD).Methods The animal model of HIBD in piglet was established.Dexamethasone was given intramuscularly in doses of 5mg·kg -1 ·d -1 and 1mg·kg -1 ·d -1 to two treatment groups respectively for 3 days.Serum of every piglet was collected at the 24th hour,the 48th hour and the 72th hour after the study began.The levels of FT 3 and FT 4 were measured by radioimmunoassay(RIA).Results The levels of FT 3 and FT 4 of HIBD group were lower than those of normal control group,especially the leves at the 48th hour( P <0.05);the leveis of FT 3 and FT 4 in the two treatment groups were both higher than those of HIBD group. Conclusion The use of dexamethasone may improve the function of the HIBD thyroid gland,but it should be given only in smaller doses to the HIE newborns.