调激宁冲剂配合激素治疗小儿原发性肾病综合征临床观察

Clinical Observation of Tiaojining Recipe in Combination with Corticosterone in Infantile Primary Nephrotic Syndrome

目的:研究调激宁冲剂配合激素治疗小儿原发性肾病综合征的作用。方法:选择60例住院患儿,随机分为两组,治疗组30例用调激宁冲剂配合激素,对照组30例单用激素,疗程均为8周。观察治疗前后尿蛋白、血清白蛋白、总胆固醇、血小板及血压的变化。结果:治疗组总有效率、完全效应率明显高于对照组(P<001),尿蛋白转阴时间明显缩短(P<005)。与对照组比较,在降低血脂、血小板、预防高血压方面亦优于对照组(P<001)。结论:调激宁冲剂能增强激素治疗小儿原发性肾病综合征的疗效,并减轻其副作用,此法安全、有效,值得推广。

To investigate the effects of Tiaojining recipe(TJNR) combined with corticosterone(CS) in treating infantile primary nephrotic syndrome(IPNS). Methods: Sixty inpatients with IPNS were divided into two groups, which consisted of 30 cases using TJNR combined with CS and 30 cases of control group were treated by CS alone for 8 weeks. The changes of urinary protein, platelet, serum albumin, blood cholesterol and blood pressure before and after treatment were observed. Results: The total effective rate of treated group was significantly higher than that of control group(P<0.01). The times for urinary protein disappearance of treated group was significantly shorter than that of control group(P<0.05). Compared with the control group, TJNR could prevent hypertension, lower hyperlipidemia and elevated platelets (P<0.01). Conclusion:TJNR could enhance the curative effects of CS on IPNS and reduce the side effects of CS, this treatment was safe and effective for IPNS.