摘要
目的 探讨大肠癌患者血清层粘连蛋白(LN)含量变化及其与肿瘤生物学特性的关系。方法 应用放射免疫技术测定15 例大肠癌患者手术前及12 例患者手术后血清LN含量。结果 大肠癌患者血清LN含量明显高于对照组(P< 0.05);淋巴结转移组明显高于无淋巴结转移组(P<0.05);Dukes′C期组高于Dukes′B期组(P< 0.05)。根治及姑息手术切除肿瘤后,血清LN 含量明显降低(P< 0.01);其中根治切除术后血清LN含量显著下降(P< 0.05),而姑息性切除术后血清LN 含量则下降不明显。结论 血清LN水平变化与肿瘤的浸润及转移过程密切相关;观察血清LN含量及其变化。
Objective To investigate the relationship between the serum laminin (LN) and the biological characteristic of tumor in patients with colorectal cancer. Methods Serum samples from 15 patients with colorectal cancer and control group were analysed. The content of LN was measured by radioimmunoassay. Results The content of LN in cancer group was significantly higher than that in control group ( P <0 05), the group with lymph node metastasis was higher than that in group without lymph node metastasis ( P <0 05), and the content of LN in Dukes′C group was higher than that in Dukes′B group ( P <0 05). After resection of the tumor the content of LN was decreased significantly ( P <0 01), especially in the group with radical resection.Conclusion The content of the serum LN is closely related to tumor invasion and metatasis, and the assay of LN in serum may be useful to the diagnosis of colorectal cancer.$$$$
出处
《肿瘤》
CAS
CSCD
北大核心
2000年第1期58-59,共2页
Tumor
