334例晚期血吸虫病超声检查与血清肝纤维化指标对照分析

Comparative analysis of ultrasonic evidences and serological findings of advanced schistosomiasis liver fibrosis

目的超声检查血吸虫性肝纤维化与血清学肝纤维化指标是否具有相关性。方法对334例晚期血吸虫病进行超声肝纤维化分级、门脉内径、腹水与血清透明质酸(HA)、层粘连蛋白(LN)、Ⅲ型前胶原(PC-Ⅲ),Ⅳ型胶原蛋白(Ⅳ-C)指标检查。结果超声检查的客观指标与血清学肝纤维化指标呈正相关。结论超声检查能反映肝纤维化严重程度,是晚期血吸虫病肝纤维化非创伤性检查的重要手段。

Objective To explore the relationship between the liver fibrosis scales of B-ultrasound and the serological indicators of advanced schistosomiasis liver fibrosis. Methods A total of 334 advanced schistosomiasis cases were classified by ultrasonic evidences, portal vein diameter and ascites were measured by B-ultrasound and serological indicators of liver fibrosis including serum hyaluronic acid （HA）, laminin （LN）, Ⅲ procollagen （PC-Ⅲ）, Ⅳcollagen （Ⅳ-C） were detected. Results There is a consistency relationship between ultrasonic evidences （including the classifications of liver fibrosis, the diameter of portal vein as well as the degree of ascites） and serological indicators in advanced schistosomiasis patients. Conclusion Ultrasonic examination can reflect the severity of liver fibrosis. It can be treated as a non-invasive detecting method for the diagnosis of advanced schistosomiasis.