血清总唾液酸和脂结合唾液酸测定对口腔颌面部恶性肿瘤的诊断意义

Prognostic significance of serum of TSA and LSA in patients with malignant tumors of oral and maxillofacial region

目的 探讨血清总唾液酸 (TSA)和脂结合唾液酸 (LSA)含量对口腔颌面部恶性肿瘤的诊断意义。方法 采用化学比色法同步检测了口腔颌面部恶性肿瘤患者TSA和LSA含量 ,并与健康对照组和口腔颌面部良性肿瘤组进行了对比分析。结果 口腔颌面部恶性肿瘤组血清TSA和LSA含量均明显高于健康对照组和良性肿瘤组 (P <0 .0 1) ,而健康对照组与良性肿瘤组之间血清TSA和LSA均无统计学意义 (P >0 .0 5 )。结论 血清TSA和LSA含量检测作为恶性肿瘤诊断的标志物 。

Objective To study the diagnostic value of TSA and LSA level in serum of the patients with maligant tumor.Methods Spectrometer was adopted to determine the TSA and LSA level in the patients with malignant tumors.We analysed the difference of TSA and LSA level in serum of patients with malignant tumors ,benign tumors and normal adults.Results The results showed that TSA and LSA in the serum of patients with oral and maxillofacial cancers were significantly higher than those in the serum of patients with benign tumor and normal adults (p< 0.01 );however,there were no difference in TSA and LSA between the patients with benign tumor and normal adults,(p> 0.05 ).Conclusion TSA and LSA may be used as tumor marker for an early diagnosis of cancer and as an prognostic indicator in malignant tumors and benign tumor in oral and maxillofacial region.