摘要
研究大鼠尾壳核神经元对黑质网状部神经元电活动的影响。通过在尾壳核注射谷氨酸钠,同时利用Plexon多通道数据采集处理系统进行黑质网状部神经元放电的胞外记录,然后运用NeuroExplorer软件对所记录的电信号进行直观分析,通过SPSS 16.0对所采集信号数据进行统计分析。实验成功在6只大鼠的黑质网状部记录到11个神经元的放电情况,麻醉状态下大鼠黑质网状部神经元放电频率为12.20±6.60 Hz,当向尾壳核注射谷氨酸钠后降低至1.80±1.00 Hz,P<0.01。化学刺激尾壳核后,黑质网状部神经元放电频率显著性降低,提示尾壳核对黑质网状部神经元有明显的抑制作用。
The article aimed to find out the effect of the neurons in nucleus caudate-putamen（CPu） on the electrical activity of neurons in the substantia nigra pars reticulate（SNr）.We injected the L-Glutamate（L-Glu）which is an incitant neurotransmitter in the brain into the CPu and meanwhile recording the neuronal extracellular discharge of the SNr.Then the discharge signals were stored in the Plexon Multichannel Acquisition Processor and were analyzed with Neuro-Explorer software,the data were statistically analyzed by SPSS 16.0 software.We recorded the discharge of 11 neurons of SNr in 6 rats,it was found that the basal firing rates of neuronal action potentials in the SNr were 12.20±6.60 Hz,but decreased to 1.86±1.00 Hz when the L-Glu was injected into the CPu,P0.01.This result suggests that the neurons of CPu have a significant inhibitory effect on neurons in the SNr.
出处
《生物医学工程研究》
2011年第3期133-137,共5页
Journal Of Biomedical Engineering Research
基金
国际合作重大项目(60910007)
国家"973"项目(20117B302106)
