荟萃分析评价呼吸系统感染促发缺血性脑中风的危险性

The Evaluation on the Risk of the Ischemic Stroke Triggered by Respiratory Infection with Meta analysis

目的：评价呼吸系统感染诱发缺血性脑中风的危险性。方法：荟萃分析。结果：对６个近期感染与缺血性脑中风（ＩＳ）发作关系的病例对照研究，对象按呼吸系统感染和非呼吸系统感染分两个层次分别进行荟萃分析，６个研究累积ＩＳ病例７１９例，有感染史者１７１例（２３．７８％），其中呼吸系统感染１１９例（１６．５５％），非呼吸系统感染５２例（７．２３％）。累积对照７７５例，有感染史者６０例（７．７４％），其中呼吸系统感染３６例（４．６５％），非呼吸系统感染２４例（３．１０％）。经齐性检验，两个层次结果一致性均很好。经加权和合并，呼吸系统感染合并ＯＲ值４．３０（２．９１～６．３６），非呼吸系统感染ＯＲ值２．５７（１．４６～４．４８）。结论：呼吸系统感染是促发ＩＳ发作的最重要的感染性疾病。

Objective:To evaluate the risk of the ischemic stroke triggered by respiratory infection.Methods:Meta analysis.Results:Subjects in 6 case control studies on the relationship between recent infection and ischemic stroke(IS) were separated into two strata:respiratory infection and non respiratory infection,and then analyzed by meta analysis.The cumulative cases were 719,among them,the patients with recent infection were 171(23 78%),of whom respiratory infection cases were 119(16 55%),other infection cases were 52(7 23%).The accumulative controls were 775,among which,the controls with recent infection were 60(7 74%),of whom respiratory infection cases were 36(4 65%),other infection cases were 24(3 1%).These 2 strata were homogenous respectively by means of homogeneity test.The pooled OR value of respiratory infection was 4 30(95% CI 2 91～6 36) and other infection was 2 57(95% CI 1 46~4 48) after being weighed and pooled.Conclusion:Respiratory infection was the most important infectious disease for ischemic stroke ictus.