代谢综合征患者肾脏病变与胰岛素抵抗的相关性研究

Study of Relationship between Metabolic Syndrome Complicated with Chronic Kidney Disease and Insulin Resistance

[目的]探讨代谢综合征患者肾脏病变与胰岛素抵抗的相关性。[方法]选取52例住院治疗的代谢综合征伴肾脏病变患者,其中胰岛素抵抗组30例,非胰岛素抵抗组22例,对B2微球蛋白(BMG)、微量白蛋白(MA)、N-乙酰-β-氨基葡萄糖苷酶(NAG)、24h微量白蛋白(24h-MA)、24h蛋白总量(24h-PRO)等五项客观测定指标进行统计学分析。[结果]MA和24h-MA在两组比较中具有统计学差异(P<0.05),而BMG、NAG和24h-PRO在这两组比较中均无明显统计学意义(P>0.05)。[结论]胰岛素抵抗与代谢综合征肾脏病变有一定的关联,MA和24h-MA是预测肾脏病变和胰岛素抵抗的两个重要指标。

[Objective] Explore the relationship between Metabolic Syndrome complicated with Chronic Kidney Disease and Insulin Resistance.[Methods] Study was conducted in 52 selected inpatients with Metabolic Syndrome complicated with Chronic Kidney Disease by logistic analysis and comparison among groups.[Results] MA and 24h-MA in IR compared to the non-IR,and the difference was statistically significant.But there was no statistical difference about BMG,NAG and 24h-PRO in IR and non-IR.[Conclusion] Insulin Resistance was associated with Metabolic Syndrome complicated with Chronic Kidney Disease,MA and 24h-MA were important factors to evaluate IR and Chronic Kidney Disease.