氨甲环酸联合还原型谷胱甘肽治疗黄褐斑的临床观察

Tranexamic Acid and Reduced Glutathione Clinical Observation of Treating Melasma

[目的]观察氨甲环酸联合还原型谷胱甘肽治疗黄褐斑的临床疗效。[方法]152例黄褐斑患者使用氨甲环酸联合还原型谷胱甘肽口服治疗,观察服药后的临床效果、疗效出现时间、不良反应等。[结果]治疗时间2～6个月,平均3.9个月。治疗后随访3个月,92.11%的患者色斑减轻;服药6个月后痊愈者13.16%、无效者7.89%;停药后色素重新加深及复发者12例,出现胃肠道反应5例,出现月经量减少4例,出现口腔溃疡1例,其余未发现其他明显的不良反应。[结论]氨甲环酸联合还原型谷胱甘肽治疗黄褐斑有较好效果,值得临床应用借鉴。

[Objective] Observation of tranexamic acid and reduced glutathione treatment of melasma the clinical efficacy.[Methods] One hundred and fifty-two patients with melasma were treated with oral administrationof tranexamic acid and reduced glutathione.A retrospective study was made on the therapeutic effect and Side effects.[Results] The treatment period was 2-6 months（mean 3.9 months）.The patients were followed for 3 months after treatment.The total improvement rate was 92.11%.After 6 months′treatment,the percentages of patients who were cured,or Invalided were 13.16% and 7.89% respectively.12 patients had recurrences.There were no obvious side effects of the treatment except 5 cases of gastrointestinal reaction,4 cases of reduced menstrual,1 case of oral ulcers.[Conclusion] Tranexamic acid and reduced glutathione treatment of melasma has good effect,worthy of clinical application and reference.