萘普待因的镇痛效应和急性毒性作用

ANALGESIC EFFECT AND ACUTE TOXICITY OF NAPRODEIN

目的··:评价萘普待因 (可待因与萘普生的比例为1 10)的镇痛作用。方法··:镇痛作用采用大小鼠醋酸扭体法和甩尾法 ,急性毒性作用采用一次给药观察7d的试验方法。结果··:大、小鼠醋酸扭体的半数有效量 (ED50)值分别为1.49和4.96mg·kg -1 ,甩尾法的ED50 值分别为0.34和0.67g·kg-1 ,都表现出明显的镇痛作用和量效关系。半数致死量 (LD50)值大、小鼠分别为0.31和1.78g·kg-1。结论··:萘普待因具有较好的镇痛作用和量效关系 ,而且可待因和萘普生在复方中表现出较好的镇痛协同作用 。

Objective:To evaluate analgesic effect and acute toxicity of naprodein (codeine : naproxen=1:10). Method: Analgesic effect was determined by acetic acid-induced writhing and tail-flicking, and acute toxicity was observed for 7 days after a single dose of the drugs(ig) in mice and rats. Result: The ED50 values were 4.96,1.49 mg·kg-1 by acetic acid-induced writhing, 0.67 and 0.34 g·kg-1 by tail-flicking in mice and rats, respectively; LD50 values were 1.78 and 0.31 g·kg-1 in mice and rats, respectively. Conclusion: analgesic effect of naprodein is better and its toxicity is lower than that of its components.