表皮生长因子对肝损害动物的保护作用

The protective effect of epidermal growth factor to liver injury animals

本实验通过建立急性肝损害动物模型 ,探讨表皮生长因子 (EGF)和雌激素的协同作用。结果表明 ,单用EGF和雌激素能改善肝脏功能 ,促进病损肝细胞的修复 ,但其作用较弱 ,而EGF在雌激素的协同下 ,能显著提高动物存活率 (P <0 .0 1) ,减轻肝组织病理损伤程度。

Aim: To probe the synergistic action of epidermal growth factor(EGF) and estrogens by establishing the animal models of acute hepatic injury. The results showed that EGF or estrogens used independently can improve the function of liver, accelerate the recovery of injured liver cell, but the action was weak. Synergistic action of EGF and estrogens could significantly increase the animal survival rate(P<0.01), and reduce pathologic injury degree of the liver tissue.