间充质干细胞移植后在体内的归巢

Homing of mesenchymal stem cells after infusion in vivo

间充质干细胞(MSCs)可由很多组织分离得到,同时也可分化成不同的组织。MSCs具有一些内在特性,如免疫抑制、组织修复、促进造血重建及减轻移植物抗宿主病(GVHD)等,这些特性使得MSCs成为研究的焦点。然而,MSCs输入动物体内后,在体内的迁移归巢、存活情况以及影响因素均不明确。该文归纳总结了相关文献后发现,影响MSCs在各组织归巢的因素很多,包括肺的滤筛作用、MSCs的数量、培养条件及病理状态等,其中病理状态(即组织损伤程度)具有关键作用。MSCs可特异性地归巢到组织损伤部位,其迁移方向遵循趋化因子浓度梯度,这一过程包括多种配体及其受体的参与。深入了解MSCs移植后在体内的归巢过程将为其在临床的应用提供理论依据。

Mesenchymal stem cells（MSCs） can be isolated from several tissues,and can also differentiate into disparate tissues.MSCs bear some capabilities such as immunosuppression,tissue repair,accelerating hematopoietic recovery and reducing graft versus host disease（GVHD）,which make MSCs the focus of researches.However,the trafficking,homing and survival of MSCs after infusion into animals and their influential factors are not clear.After reviewing papers,here we reveal some factors influencing homing of MSCs in vivo such as filtration of lung,quantity and culture condition of MSCs and pathologic status of tissues,among which pathologic status（severity of tissue injury） plays a critical role.MSCs preferentially home to sites of tissue injury,the trafficking direction is in line with the chemokine density gradient,and this progress is associated with many ligands and their receptors.Comprehension of homing of mesenchymal stem cells after infusion in vivo may contribute to providing theoretical foundation for clinical utilization of MSCs.