昆虫先天免疫的肽聚糖识别蛋白的研究进展

Study of Peptidoglycan Recognition Proteins in the Innate Immunity of Insect

先天免疫系统的激活是通过一系列高度保守的模式识别受体识别病原体相关分子模式。肽聚糖识别蛋白家族是重要的模式识别受体,从昆虫到人类均高度保守,可识别肽聚糖和含肽聚糖的细菌,在先天免疫和获得性免疫应答中发挥重要的识别和调节功能。

The innate immune system recognizes pathogen-associated molecular pattern through a series of pattern recognition receptors.As important pattern recognition receptors,peptidoglycan recognition proteins,which are highly conserved from insect to human,can recognize peptidoglycan or bacteria containing peptidoglycan,and they have important functions of recognizing and regulating in both innate and adaptive immunity.