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活性维生素D及其类似物对足细胞的保护作用 被引量：9

Podocytes as target of 1,25-dihydroxyvitamin D_3 and its analogs
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摘要 1,25(OH)2D3产生不足是慢性肾脏病(CKD)的主要特征之一,不仅导致钙磷代谢异常及骨矿化障碍,而且加速肾疾病的进展。1,25(OH)2D3及其类似物可减轻CKD患者的蛋白尿,减轻动物模型足细胞的损伤、凋亡和脱落,促进裂孔隔膜蛋白的表达,维持肾小球滤过屏障的完整性。1,25(OH)2D3保护足细胞机制与抑制足细胞肾素-血管紧张素系统、阻断Wnt/β-Catenin和转化生长因子(TGF)-β1信号通路有关。 1, 25 （OH）2D3 deficiency is a prominent feature of chronic kidneydiseases （CKD）. It not only leads to abnormalities of calcium and phosphorus metabolism and bone mineralization in CKD patients, but also accelerates the progression of kidney disease. It has been found that 1, 25 （OH）2D3 and its analogs can reduce proteinuria in CKD patients, ameliorate podocyte injury .and loss, promote the expression of slit diaphragm proteins, and maintain the integrity of the glomerualr filtration barrier in animal moders. The mechanisms of 1, 25 （OH）2D3 and its analogs protecting podoeyte involve inhibiting rennin-angiotensin system and blocking Wnt/β-catenin and TGF-β1 signaling pathways in podocytes.
作者 邹敏书 余健 周建华
机构地区 广州军区武汉总医院儿科 华中科技大学同济医学院同济医院儿科
出处 《临床儿科杂志》 CAS CSCD 北大核心 2012年第1期93-96,共4页 Journal of Clinical Pediatrics
关键词 维生素D 足细胞 慢性肾疾病 vitamin D podocyte chronic kidney disease
分类号 R692 [医药卫生—泌尿科学]
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参考文献30

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二级参考文献28

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共引文献3

同被引文献116

  • 1王凤英,卢思广,赵彤,李国民.系膜增生型原发性肾病综合征患儿细胞毒性T淋巴细胞相关抗原4基因多态性、蛋白表达及外周血淋巴细胞凋亡的研究[J].中华儿科杂志,2007,45(8):633-634. 被引量：5
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引证文献9

二级引证文献56

临床儿科杂志
2012年 第1期

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