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高迁移率族蛋白B1与心血管疾病相关性的研究进展 被引量：4

Progress in relationship between high mobility group box 1 protein and cardiovascular diseases
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摘要 高迁移率族蛋白B1(high mobility group box1 protein,HMGB1)是一种核蛋白质,其可由坏死细胞以及活化的免疫细胞释放至细胞外而具有细胞因子的活性,继之启动免疫反应和引发炎性反应。近年来,大量研究证实HMGB1与心力衰竭(heart failure,HF)、心肌缺血-再灌注(ischemia/reperfusion,I/R)损伤、动脉粥样硬化(atherosclerosis,AS)、心肌梗死(myo-cardial infarction,MI)等疾病有密切关系,通过研究HMGB1在心血管疾病发生发展过程中的机制,可为心血管疾病的临床治疗找到新靶点。 High mobility group box 1 protein（HMGB1） is a kind of nucleoprotein.It is secreted by necrosis cells and activated immunocytes into the extracellular environment,which has the activity of a cytokine,and thereby initiates immune responses and cause inflammatory reactions.It has been confirmed by numerous studies that HMGB1 is closely related to heart failure,myocardial ischemia reperfusion injury,atherosclerosis,heart infarction,etc.Studying the mechanism of HMGB1 in the development of angiocardiopathy will find a new target for curing cardiovascular diseases clinically.
作者 刘宇 曹清心 赵仙先
机构地区 第二军医大学长海医院心血管内科 第二军医大学长海医院中医科
出处 《医学研究生学报》 CAS 北大核心 2012年第1期99-102,共4页 Journal of Medical Postgraduates
关键词 高迁移率族蛋白B1 炎性反应 心血管疾病 心力衰竭 心肌缺血-再灌注损伤 动脉粥样硬化 心肌梗死 High mobility group box 1 protein Inflammatory reaction Cardiovascular disease Heart failure Myocardial ischemia reperfusion injury Atherosclerosis Myocardial infarction
分类号 R542.22 [医药卫生—心血管疾病]
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参考文献35

  • 1Goodwin GH,Sanders C,Johns EW.A new group of chromatinassociated proteins with a high content of acidic and basic amino acids[J].Eur J Biochem,1973,38 (1):14-19.
  • 2Müller S,Ronfani L,Bianchi ME,et al.Regulated expression and subcellular localization of HMGBI,a chromatin protein with a cytokine function[J].J Intern Med,2004,255 (3):332-343.
  • 3Bianchi ME,Manfredi A.Chromatin and cell death[J].Biochim Biophys Acta,2004,1677 (1-3):181-186.
  • 4Rauvala H,Rouhiainen A.RAGE as a Receptor of HMGBI (Amphoterin):Roles in Health and Disease[J].Curr Mol Med,2007,7 (8):725-734.
  • 5Degryse B,de Virgilio M.The nuclear protein HMGB1,a new kind of chemokine[J].FEBS Lett,2003,553(1-2):11-17.
  • 6Lildballe DL,Pedersen DS,Kalamajka R,et al.The Expression Level oh the Chromatin-Associated HMGB1 Protein Influences Growth,Stress Tolerance,and Transcriptome in Arabidopsis[J].J Mol Biol,2008,384(1):9-21.
  • 7Calogero S,Grassi F,Aguzzi A,et al.The lack of chromosomal protein Hmgbl does not disrupt cell growth but causes lethal hypoglycaemia in newborn mice[J].Nat Genet,1999,22 (3):276-280.
  • 8Taguchi A,Blood DC,del Toro G,et al.Blockade of RAGE-amphoterin signalling suppresses tumor growth and metastases[J].Nature,2000,405 (6784):354-360.
  • 9Yang H,Ochani M,Li J,et al.Reversing established sepsis with antagonists of endogenous high-mobility group box 1[J].Proc Natl Acad Sci USA,2004,101 (1),296-301.
  • 10Park JS,Arcaoli J,Yum HK,et al.Activation of gene expression in human neutrophils by high mobility group box 1 protein[J].Am J Physiol Cell Physiol,2003,284 (4):C870-C879.

二级参考文献42

  • 1胡波,许珏,陈忠诚,吴宗华,罗敏琪.2型糖尿病患者IL-2,IL-6及TNF-α水平检测[J].广东医学,2006,27(5):735-737. 被引量：15
  • 2王劲松.2型糖尿病肾病患者血清IL-2、SIL-2R和TNF-α检测的临床意义[J].放射免疫学杂志,2007,20(2):109-110. 被引量：5
  • 3Lerner DJ,Kannel WB.Patterns of coronary heart-disease mor-bidity and mortality in the sexes-a 26-year follow-uo of the fram-ingham population[J].American Heart,1986,111(2):383-390.
  • 4Manuel DG,Leung M,Nguyon K,et al.Burden of cardiovascu-lar disease in Canada[J].Canadian Cardiol,2003,19(9):997-1004.
  • 5Thom T,Haase N,Rosamond W,et al.Heart disease and strokestatistics—2006 update:A report from the American Heart Asso-ciation Statistics Committee and Stroke Statistics Subcommittee[J].Circulation,2005,113(4):85-151.
  • 6Mercuro G,Deidda M,Piras A,et al.Gender determinants ofcardiovascular risk factors and diseases[J].J Cardiovasc Med(Hagerstown),2010,11(3):207-220.
  • 7Anon.Obesity:Preventing and managing the global epidemic-in-troduction[J].WHO Technical Report Sevise,2000,894(6):88-91.
  • 8World HO.Clinical guidelines on the identification,evaluation,and treatment of overweight and obesity in adults-the evidence re-port.National institutes of health[J].Obes Res,1998,6(Sup-pl 2):51-57.
  • 9Rao SV,Donahue M,Pisunyor FX,et al.Obesity as a risk fac-tor in coronary artery disease[J].American Heart,2001,142(6):1102-1107.
  • 10Eckel RH,Krauss RM,Comm AHAN.American heart associa-tion call to action:Obesity as a major risk factor for coronaryheart disease[J].Circulation,1998,97(21):2099-2100.

共引文献16

同被引文献43

  • 1Heymans S, Hirsch E, Anker SD, et al. Inammation as a thera- peutic target in heart failure A scientic statement from the transla- tional research committee of the heart Failure association of the european society of cardiology [ J ]. Eur J Heart Fail, 2009,11 (2) :119-129.
  • 2Bustin M. Regulation of DNA-dependent activities by the func- tional motifs of the high-mobility-group chromosomal proteins [ J ]. Mol Cell Biol, 1999,19 ( 8 ) :5237-5246.
  • 3Yamada S,Maruyama I. HMGB1, a novel inflammatory cytokine [ J ]. Clin China Acta,2007,375 ( 1-2 ) :36-42.
  • 4Armstrong PW, Granger CB, Adams PX, et al. APEX AMI Investi- gators. Pexelizumab for acute ST-elevation myocardial infarction in patients undergoing primary percutaneous coronary intervention: A randomized controlled trial [ J ]. JAMA, 2007, 297 ( 1 ) : 43- 51.
  • 5Taguchi A,Blood DC,del Toro G, et al. Blockade of RAGE am- photerin signalling suppresses tumor growth and metastases [ J ]. Nature,2000, 405 (6784) :354-360.
  • 6Yang H, Ochani M, Li J, et al. Reversing established sepsis with antagonists of endogenous high mobility group box 1 [ J ]. Proc Natl Acad Sci USA,200g, 101 (1) ,296-301.
  • 7Andrassy M, Volz HC, Igwe JC,et al. High-mobility group box-1 in ischemia-reperfusion injury of the heart [ J ]. Circulation, 2008, 117 (25) :3216-3226.
  • 8Kitahara T, Takeishi Y, Harada M, et al. High-mobility group box 1 restores cardiac function after myocardial infarction in transgen- ic mice[ J]. Cardiovasc Res,2008, 80 ( 1 ) : 40-46.
  • 9Limana F, Germani A, Zacheo A, et al. Exogenous high-mobility group box 1 protein induces myocardial regeneration after infarc- tion via enhanced cardiac C-kit + cell proliferation and differenti- ation[J]. Circ Res, 2005, 97 (8) :e73-e83.
  • 10VanEeden S,Leipsic J.Paul Man SF,et al. The relationshipbetween lung inflammation and cardiovascular disease [J].American journal of respiratory and critical care medicine,2012f186(1);11-16.

引证文献4

二级引证文献22

医学研究生学报
2012年 第1期

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