经皮冠状动脉介入术对血清MMP-9和超敏C-反应蛋白水平的影响

Effects of percutaneous coronary intervention on the level of Matrix Metallo Proteinases-9 and hypersensitive C-reactive protein

目的探讨经皮冠状动脉介入术(PCI)的效果及对血清基质金属蛋白酶-9(MMP-9)和超敏C-反应蛋白(hs-CRP)水平的影响。方法 110例冠心病患者,行PCI(PTCA/PTCA+支架术),观察疗效,测定MMP-9和hs-CRP水平变化。结果 110例患者共安置支架126枚,支架全部成功地置入靶血管病变部位;有1例双支病变患者因导丝不能通过前降支狭窄部位放弃,3例患者发生无再流现象,手术成功率为96.4%。术后MMP-9水平明显降低,hs-CRP水平明显增高(P<0.01)。结论 PCI对冠心病的治疗效果是满意的,监测血清MMP-9和hs-CRP水平可了解PCI治疗效果和炎症程度。

Objective To investigate the effects of percutaneous coronary intervention on the level of Matrix Metallo Proteinases-9（MMP-9） and hypersensitive C-reactive protein（hs-CRP）.Methods The blood of patients with coronary heart disease before and after PCI were collected to measure the serum level of MMP-9 and hs-CRP. Results There were 126 heart stents successfully placed all the target vessel lesions but one for the guide wire could not through descending anterior branch.3 patients following PCI had no-reflow phenomenon.The rate of success of operation was 86%.After PCI,the level of MMP-9 significantly decreased,and level of MMP-9 significantly increased（P0.01）.Conclusion The therapeutic effect of PCI is good. It is helpful for knowing therapeutic effect of PCI and inflammation degree to monitor the serum level of MMP-9 and hsCRP.