14例复发型吉兰-巴雷综合征临床特征分析

The analysis of clinical features of 14 cases of Recurrent Guillain-Barre Syndrome

目的了解复发型吉兰-巴雷综合征(Guillain-Barre Syndrome,GBS)的临床特征,增加对该罕见GBS变异类型的认识。方法对郑州大学第一附属医院于1998～2004年收住的395例GBS患者中14例复发型的临床特征进行分析,并与非复发型的临床特征进行比较。结果复发率低,为3.5%,男性多于女性,病前多有感染史,首发症状、达峰时间、辅助检查(如肌电图、脑脊液、免疫球蛋白等)、治疗及预后均与非复发型类似,但达峰症状较非复发型重,呼吸肌麻痹比例较非复发型高。结论复发型GBS是GBS的罕见变异型,临床特征与GBS相似,但程度较重。

Objective To explore the clinical features of Recurrent Guillain-Barre Syndrome（RGBS）and enhance the knowledge of the uncommon variant of Guillain-Barre Syndrome（GBS）.Methods 395 cases of patients with GBS who were admitted to the First Affiliated Hospital of Zhengzhou University from 1998 to 2004 were enrolled,in which 14 cases of recurrent type were found.Their clinical features was analyzed and compared with cases of no recurrent type.Results The recurrent rate was 3.5%.Male outnumbers female.There was always infections before the onset.The onset symptom,peak time,assistant examination（EMG,ESF,Immunoglobulin）,treatment and prognosis is similar to no recurrent type.But the peak symptom of RGBS was severer than NRGBS.The rate of respiratory muscular paralysis of RGBS was higher than NRGBS.Conclusion RGBS is an uncommon type of GBS.The clinical features of it is similar to GBS.But the severity is worse than GBS.