心衰患者甲状腺激素变化分析

Significance of Change in Thyroid Hormone in Patients with Heart Failure

目的探讨慢性心力衰竭(CHF)患者血清甲状腺激素(TH)的变化及其临床意义。方法采用放免法测定89例慢性心力衰竭患者及40例门诊健康体检者血清三碘甲状腺原氨酸(T3)、甲状腺素(T4)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)及促甲状腺素(TSH)的水平并比较。结果慢性心力衰竭患者与对照组比较,血清T3、FT3、T4均降低(P<0.05或P<0.01),FT4、TSH无明显变化(P>0.05);T3、FT3、T4随心衰程度加重逐渐降低(P<0.05或P<0.01);TSH在心衰各亚组间比较差异无统计学意义(P>0.05)。结论慢性心力衰竭患者常伴有正常甲状腺功能病态综合征,其甲状腺衰竭激素水平的变化程度与心衰严重程度相关。

Objective To investigate the change of thyroid hormone（TH） in patients with chronic heart failure（CHF） and its clinic significance.Methods The levels of TH（T3,T4,FT3,FT4 and TSH） from 89 patients with CHF and 40 normal controls were measured by radio-immunity method.Results The levels of T3,T4,FT3 in CHF group were significantly lower than that in normal controls（P0.05 or P0.01）;The levels of T3,T4 and FT3 went down gradually along with heart function decrease（P0.05 or P0.01）;The levels of THS in both groups had no statistical difference（P0.05）.Conclusion CHF is usually combined with Euthyroid sick syndrome.The levels of TH are well correlated with the seriousness of CHF.