神经生长因子及其受体TrkA、p75NTR在隆凸性皮肤纤维肉瘤和皮肤纤维瘤中的表达

Expressions of nerve grow th factor and its receptors TrkA and p75NTR in dermatofibrosarcoma protuberans and dermatofibroma

目的 探讨神经生长因子（NGF）及其受体酪氨酸激酶A（TrkA）、p75神经营养因子受体（p75NTR）在隆凸性皮肤纤维肉瘤和皮肤纤维瘤中的表达. 方法 应用免疫组化ABC法检测隆凸性皮肤纤维肉瘤石蜡标本17例、皮肤纤维瘤石蜡标本15例中NGF及其受体TrkA、p75NTR表达.结果 NGF及TrkA在隆凸性皮肤纤维肉瘤及皮肤纤维瘤中均呈高表达,两者之间差异无统计学意义（x2=0.11,0.02,P值均＞0.05）；而p75NTR在隆凸性皮肤纤维肉瘤中的表达显著高于皮肤纤维瘤（x2=32,P＜0.01）,且NGF与p75NTR在隆凸性皮肤纤维肉瘤表达呈正相关（R2=0.623,P＜ 0.01）.结论 NGF可能通过其高亲和受体TrkA及低亲和受体p75NTR在隆凸性皮肤纤维肉瘤的发病中起一定作用.

Objective To investigate the expressions of nerve growth factor （NGF） and its receptors TrkA and p75NTR in dermatofibrosarcoma protuberans and dermatofibroma. Methods Avidin-biotin immunohistochemical （ABC） method was used to detect the expressions of NGF and its receptors TrkA and p75NTR in paraffin-embedded tissue specimens from 17 cases of DFSP and 15 cases of dermatofibroma.Results NGF and TrkA were highly expressed in both DFSP and dermatofibroma specimens,with no significant difference between the two groups of specimens （x2 =0.11,0.02,respectively,both P 〉 0.05）,while the expression of p75NTR was significantly higher in DFSP than in dermatofibroma specimens （x2 =32,P 〈 0.01 ）.The expression of NGF was positively correlated with that of p75NTR in DFSP （R2 =0.623,P 〈 0.01 ）.Conclusion NGF may play a certain role in the development of DFSP via its high-affinity receptor TrkA and low-affinity receptor p75NTR.