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瑞他莫林——一种新的外用抗菌药

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摘要 皮肤与软组织感染是皮肤科常见病，而细菌对常用的外用抗菌药物的耐药性正在全球范围内增加，这些药物包括莫匹罗星与夫西地酸。如金黄色葡萄球菌对莫匹罗星的耐药率在拉丁美洲为1．3％，欧洲为8．7％，美国为32．5％；凝血酶阴性的葡萄球菌对莫匹罗星的耐药率欧洲为12．7％，
作者 李奇 徐文严
机构地区 中国医学科学院北京协和医学院皮肤病研究所
出处 《中华皮肤科杂志》 CAS CSCD 北大核心 2012年第2期147-149,共3页 Chinese Journal of Dermatology
关键词 抗菌药物 外用 金黄色葡萄球菌 莫匹罗星 软组织感染 夫西地酸 拉丁美洲 皮肤科
分类号 R446.5 [医药卫生—诊断学]
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参考文献17

  • 1Jones RN,Fritsche TR,Sader HS,et al.Activity of retapamulin (SB-275833),a novel pleuromulin against selected gram-positive cocci.Antimicrob Agents Chemother,2006,50(7):2583-2586.
  • 2Shah M,Mohanraj M.High levels of fusidic acid-resistant Staphylococcus aureus in dermatology patients.Br J Dermatol,2003,148(5):1018-1020.
  • 3Pankuch GA,Lin G,Hoellman DB,et al.Activity of retapamulin against Streptococcus pyogenes and Staphylococcus aureus,evaluated by agar dilution,microdilution,E-test,and disk diffusion methodologies.Antimicrob Agents Chemother,2006,50 (5):1727-1730.
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二级参考文献3

  • 1Odou M F, Miler C, Calvet L, et al. In vitro activity against anaerobes of retapamulin, a new topical antibiotic for treatment of skin infections. J Antimicrob Chemother,2007,59:646.
  • 2Free A, Both E, Dalessandro M, et al. Retapamulin ointment twice daily for 5 days vs oral cephalexin twice daily for 10 days for empiric treatment of secondarily infected traumatic lesions of the skin. Skinmed, 2006,5 : 224.
  • 3Parish L C, Jorizzo J L, Breton J J, et al. Topical retapamulin ointment ( 1% wt/wt) twice daily for 5 days versus oral cephalexin twice daily for 10 days in lhe treatment of secondarily infected dermatitis: resets of a randomized controlled trial. J Am Aead Dermatol,2006,55:1003.

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中华皮肤科杂志
2012年 第2期

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