压力性尿失禁的细胞治疗

CELLULAR THERAPY OF STRESS URINARY INCONTINENCE

目的综述压力性尿失禁(stress urinary incontinence,SUI)细胞治疗的研究现状及临床应用进展。方法广泛查阅近年来有关SUI细胞治疗的文献并进行综述。结果软骨细胞和成肌细胞因不具有或仅有较差的再生修复能力,限制了二者的临床应用;干细胞因具有较强的自我更新和再生修复能力被认为是治疗SUI的理想种子细胞,已在动物实验及初步临床研究中取得了令人振奋的成果,为SUI细胞治疗可行性奠定了理论基础。结论细胞治疗尤其是干细胞治疗为SUI提供了一种新的治疗手段,其具体作用机制还有待进一步研究。

Objective To review the progress and clinical application of cellular therapy for stress urinary incontinence （SUI）. Methods The literature about cellular therapy of SUI was extensively reviewed. Results Because of having no or poor regeneration capacity, the clinical application of chondrocytes and myoblasts were limited. Based on the rapid progress in stem cell biology, an increasing number of animal experiments and clinical trials about cellular therapy of SUI have been reported with encouraging results. All these show that cellular therapy has great potential in dinical application. Stem cells are considered as ideal seeded-cells for treatment of SUI. Conclusion Cellular therapy, especially stem cells, provides a novel approach for treatment of SUI, but the mechanism needs further study.