神经干细胞与BMSCs移植治疗脊髓损伤的研究进展

TRANSPLANTATION OF NEURAL STEM CELLS AND BONE MARROW MESENCHYMAL STEM CELLS IN TREATMENT OF SPINAL CORD INJURY

目的综述神经干细胞(neural stem cells,NSCs)与BMSCs的免疫学特性及治疗脊髓损伤(spinal cordinjury,SCI)的新进展。方法广泛查阅近年国内外相关文献,对NSCs与BMSCs的免疫学特性、移植治疗SCI的实验研究与可能存在的问题进行分析。结果动物实验表明NSCs与BMSCs移植可促进SCI动物行为学改善,但由于两种干细胞的免疫学特性,同种异体干细胞移植后将产生免疫排斥反应。结论 NSCs与BMSCs对SCI有很好的治疗效果,但是免疫排斥问题值得考虑。

Objective To review the progress in the treatment of spinal cord injury （SCI） by graft of neural stem cells （NSCs） or bone marrow mesenchymal stem cells （BMSCs） as well as immune characteristics of two stem cells. Methods Different kinds of documents were widely collected, and then immunologic characteristic of NSCs and BMSCs were summarized. The therapy of SCI by stem cell transplantation was reviewed. Additionally, some problems in treatment were analyzed. Results Experimental study showed that graft of NSCs and BMSCs can promote the functional recovery of the injured spinal cord in animals. Due to immunologic properties of two stem cells, rejection reaction of transplantation could produce a harmful effect on SCI treatment. Conclusion Transplantation of NSCs or BMSCs Might be an effective measure for SCI treatment, but immunologic rejection reaction must be considered.