子宫颈上皮内瘤变的高危型HPV负荷量对治疗后复发的影响

Effect of high-risk human papillomavirus load of cervical intraepithelial neoplasia on postoperative recurrence

目的探讨术前子宫颈上皮内瘤变(CIN)的高危型人乳头瘤病毒(HR-HPV)的负荷量与CIN治疗后复发的关系。方法选择205例CIN患者,术前均采用第二代杂交捕获法(hybrid captureⅡ,HC-Ⅱ)检测HPV负荷量,术后6-8月于阴道镜下行子宫颈活检病理检查。结果术前HR-HPV负荷量与CIN呈等级正相关(r=0.4288,P<0.01),经6-8月随访,发现25例CIN复发,其术前HR-HPV负荷量均>1 000 RLU/CO,术后CIN复发与术前HR-HPV负荷高负荷量有关(P<0.01),与术前CIN级别无关(P<0.01)。结论 CIN术前HR-HPV高负荷量(>1 000 RLU/CO)可增加术后CIN复发的危险性。

Objective To investigate the correlations of high-risk HPV load of CIN to the abnormal cytology after surgery. Methods 205 CIN patients received high-risk HPV load detection using hybrid capture Ⅱ（HC-Ⅱ）and thin-layer liquid based-cytology（LCT） before operations and were followed up for 6-8 months. Results After follow-up of 6-8 months,25 patients were found abnormal cytological smear again,whose HPV loads were all over 1 000 RLU/CO berore operation.The abnormal cytology after operation related to the high-risk HPV load（P〈0.01）,had no relation to CIN grades（P〈0.01）. Conclusion HR-HPV high load（the viral load of over 1 000 RLU/CO） can increase the risk of surgical recurrence.