摘要
Photodynamic therapy (PDT) is a very effective treatment for port wine stains (PWS). To guide and assess PDT treatment, a handheld optical coherence tomography (OCT) probe was designed for real-time imaging of the PWS patient. The system uses a light source with a center wavelength of 1310 nm, -3 dB bandwidth of 90 nm and an optical power of 9 mW. The system also has a spatial resolution of 8 μm (lateral) × 7 μm (axial), an imaging rate of 4 frames per second, and a 102 dB sensitivity. We then demonstrate that the OCT imaging system can clearly distinguish between normal and PWS tissues. Therefore, the system can provide valuable guidance for PDT treatment.
Photodynamic therapy （PDT） is a very effective treatment for port wine stains （PWS）. To guide and assess PDT treatment, a handheld optical coherence tomography （OCT） probe was designed for real-time imaging of the PWS patient. The system uses a light source with a center wavelength of 1310 nm, -3 dB bandwidth of 90 nm and an optical power of 9 mW. The system also has a spatial resolution of 8 μm （lateral）× 7μm （axial）, an imaging rate of 4 frames per second, and a 102 dB sensitivity. We then demonstrate that the OCT imaging system can clearly distinguish between normal and PWS tissues. Therefore, the system can provide valuable guidance for PDT treatment.
基金
supported in part by the National High-Tech Research and Development Program of China (2006AA02Z472)
National Basic Research Program of China (001CB510307 and 2009CB929400)
National Natural Science Foundation of China (90508001, 10676014 and 10574081)
Tsinghua University Initiative Scientific Research Program
