摘要
本实验用三氧化二锑(Sb_2O_3)对大鼠进行多次连续性染尘,分次观察肺干重、肺胶原蛋白及肺组织病理改变。发现随染尘次数增加,肺干重夏肺胶原蛋白含量逐渐增加并出现显著性差异(P>0.01,P>0.05)。病理观察可见细胞一纤维性结节。提示长期反复吸入Sb_2O_3粉尘,可引起肺组织一定程度的纤维化病变。
Rats were exposed repeatedly to Sb_2O_3 powders by intratreacheal instillation. The treated rats were killed by batch at interval of 1.5 month after administration. The result showed that the increase of pulmonary dry weight and collagen content was associated with the number of intratreacheal instillation, being significantly higher than that in the control group, but lower than that in the group treated by quartz. The cellular fibrotic nodules and interstitial fibrosis were also shown in the exposed groups. It indicated that long term inhala- ??tion of Sb_2O_3 dust would in certain extent induce pulmonary fibrosis.
出处
《职业医学》
1990年第4期203-204,255-256,共2页
China Occupational Medicine
