非嗜肝病毒所致急性黄疸性肝炎的疗效观察

目的探讨腺苷蛋氨酸对非嗜肝病毒所致急性肝炎高胆红素血症的疗效。方法选择总胆红素﹥85.5μmol/L的非嗜肝病毒所致的急性肝炎伴高胆红素血症患者32例,随机分为治疗组17例和对照组15例,两组均给予内科基本治疗,治疗组加用腺苷蛋氨酸1000mg,静滴,qd;对照组予以苦黄注射液30ml,静滴,qd,治疗4周,比较两组疗效的差异。结果治疗组腹胀、乏力、纳差症状的改善率明显优于对照组(P﹤0.05),治疗组血清总胆红素的下降程度明显大于对照组;肝功能复常率及总有效率均高于对照组,且复常时间明显快于对照组(P﹤0.05),未观察到腺苷蛋氨酸相关的任何不良反应发生。结论腺苷蛋氨酸治疗非嗜肝病毒所致急性肝炎高胆红素血症,疗效确切,可缓解患者皮肤瘙痒、乏力、纳差等临床症状。

Objective To observe the therapeutic effect of ademetionine in treating acute icteric hepatitis caused by non-hepatotropic virus. Methods 32 cases of hyperbilirubinemia-non-hepatotropic virus hepatitis patients（whose serum total bilirubin（STB）more than 85.5μmol/L）were randomly divided into treatment group（n=17） and control group（n=15）. The same basic therapy was applied to the two groups. Ademetionine was given to the treatment group with a dosage of 1000mg intravenous drip once a day for 4 weeks. The therapeutic effect on patients in the two groups were compared. Results The efficiency for the belly swell, fatigue or anorexia in treatment group was better than control group（P〈0.05）. For acute ieteric hepatitis（AIH） caused by non-hepatotropic virus, the efficiency for liver function returning to normal and the total efficiency in treatment group were higher than control group（P〈0.05）. The time for the liver function returning to normal for AIH caused by non-hepatotropic virus in the treatment group were shorter than that of the control group（P〈0.05）.The degree of STB declined in the treatment group were more than that of the control group（P〈0.05）. No side effect related to Ademetionine was found. Conclusion Ademetionine is an effective assistant drug for the treatment of AIH caused by non-hepatotropic virus. It can also be used to alleviate clinical Sympto-ms（the dermatic pruritus, fatigue and anorexia） of patients with hyperbilirubinemia- non-hepatotropic virus hepatitis.