摘要
为了研究左卡尼汀(L-carnitine,LC)对D-半乳糖所致衰老小鼠的抗氧化作用,试验将50只小鼠随机分成5组,即空白对照组、模型组和左卡尼汀治疗组[0.25、0.50、1.00 g/(kg.d)],采用D-半乳糖复制亚急性衰老小鼠模型,试验6周后处死小鼠,测定其血浆、脑组织及肝脏中的超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)活性及丙二醛(MDA)含量。试验结果显示,左卡尼汀能显著提高衰老小鼠血清、脑组织及肝脏中的SOD、GSH-Px活性,降低MDA含量,且呈剂量依赖性。表明左卡尼汀有一定的抗衰老作用,其机制可能与抗氧化作用有关。
50 mice were randomly allocated to 5 groups to study the antioxidant effects of L-carnitine on D-galactose induced aging mice.Apart from a control group,D-galactose model group,the LC treatment groups were at three level such as 0.25,0.50 and 1.00 g/kg·d.Using the subacute D-galactose induced aging model,the mice were killed after 6 weeks of experiment and detected the level of SOD,GSH-Px and MDA in the blood,brain and liver tissue.The results showed that the activity of SOD and GSH-Px in blood,brain and liver tissue were significantly increased after treated with L-carnitine,while the contents of MDA were decreased.It indicated that the L-carnitine had anti-aging effects in mice,and the mechanism might be correlated with its antioxidation.
出处
《湖北农业科学》
北大核心
2012年第1期129-130,135,共3页
Hubei Agricultural Sciences
