石英粉尘对人工细胞膜的损伤及柠檬酸铝的抗损作用研究：对膜蛋白的吸附...

Interaction of quartz with erythrocyte membranes: Adsorption of membrane proteins and anti-adsorptive activity of aluminium citrate.

本文观察了石英粉尘在体外对人红细胞膜蛋白的吸附作用和柠檬酸铝抗吸附作用。石英对红细胞膜蛋白的吸附作用存在着时间效应和剂量效应的关系。柠檬酸铝具有拮抗石英吸附膜蛋白的作用。提示石英对红细胞膜的损伤过程中,与膜蛋白的相互影响作用有一定关系。铝离子改变石英表面活性,可以减轻其对膜蛋白的影响。

The adsorption of erythrocyte membrane proteins on to quartz particles was studied. At 4℃ of incubation the adsorption appeared to be dose-and time-dependent. The aluminium citrate could strongly inhibit the adsorptive activity of quartz. The results supported the idea that the membrane toxicity of quartz is related to quartz-protein interaction. When quartz surfaces are covered with aluminum, its effect on membrane proteins will be reduced.