期刊文献+

沙利度胺对三阴乳腺癌干细胞微球体的干预研究 被引量:5

下载PDF
导出
摘要 目的:以紫杉醇为对照,研究沙利度胺(thalidomide,TLD)对三阴乳腺癌干细胞(TNBCSCs)微球体的干预情况。方法:(1)采用微球体形成试验、CCK-8法、Transwell侵袭试验,研究TLD对TNBCSCs生物学行为的影响作用。(2)采用逆转录聚合酶链反应法(RT-PCR)检测TLD对TNBCSCs的血管内皮生长因子(VEGF)表达的影响。结果:与空白对照组相比,TLD处理后的微球体形成率明显减少,同时干细胞的增殖、侵袭能力均降低,VEGF的表达下降明显,差异有统计学意义。结论:TLD可以影响干细胞微球体的形成,抑制其体外增殖、侵袭及VEGF的表达。
出处 《实用医学杂志》 CAS 北大核心 2012年第3期361-363,共3页 The Journal of Practical Medicine
  • 相关文献

参考文献5

  • 1Bosch A,Eroles P,Zaragoza R,et al.Triple-negative breast cancer; molecular features,pathogenesis,treatment and current lines of research[J].Cancer Treat Rev,2010,36(3):206-215.
  • 2Foulkes W D,Smith I E,Reis-Filho J S.Triple-negative breast cancer[J].N Engl J Med,2010,363(20):1938-1948.
  • 3Pal A,Valdez K E,Carletti M Z,et al.Targeting the perpetrator; breast cancer stem cell therapeutics[J].Curr Drug Targets,2010,11(9):1147-1156.
  • 4张雁.肿瘤干细胞及其治疗对策[J].实用医学杂志,2011,27(14):2499-2501. 被引量:4
  • 5窦俊,主编.肿瘤干细胞[M].南京:东南大学出版社:2009,121.

二级参考文献20

  • 1Bonnet D, l)iek J E. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell [J]. Nat Med, 1997,3(7):730-737.
  • 2Garwicz S, Bekassy A N, Schmiegelow K, el al. Distinct patterns of hematopoietic slem cell involvement in acute lymphoblastic leukemia [ J ]. Nat Med, 2005,11 (6) : 630-637.
  • 3Calabretta B, t'errotti D. The biology of CML blast crisis [Jl. Blc, od. 2004 103( 11 ) .4010-4027.
  • 4A1-Hajj M, Wicha M S, Benito-Hernandez A, et al. Prospective identii'ication of tumorigenic breast cancer cells iJ J. Proc Natl Acad Sci USA, 2003,100(7) :3983-3988.
  • 5Schatton T, Mutthy G F, Frank N Y, ct aI. Identification of cells initiating human melanomas [J]. Nature, 2008,451 (7176) :345-349.
  • 6Yang Z F, Ho D W, Ng M N, ctal. Significance of CD90+ cancer stem cells in human liwr cancer [J]. Cancer Cell, 2008,13(2) : 153-166.
  • 7Collins A T, Berry P A, Hyde C, et al. Prospective identification of tumorigenic prostate cancer stem ceils [J]. Cancer Res, 2005,65(23) : 10946-10951.
  • 8Dalerba P, Dylla S J, Park I K, et al. Phenotypic characterization of human cnlnrectal cancer stem cells [J]. Proc Natl Acad Sci USA, 2007, 104(24) : 10158-10163.
  • 9Eramo A, Lotti F, Sette G, et al. dentification and expansion of the tumorigenic lung cancer stem cell population [J]. Cell Death Differ, 2008,15(3) :504-514.
  • 10Hermann P C, Huber S I,, Herrler T, et al. Distinct populations of cancer stem cells determine lumor growth and metastatic activity in human pancreatic can(:er [J ]. Cell Stem Cell, 2007,1(3) :313-323.

共引文献4

同被引文献82

  • 1李瑞.药理学[M].北京:人民卫生出版社,2007:300-304.
  • 2Kau P, Nagaraja GM, Zheng H, et al. A mouse model for triple- negative breast cancer tumor-initiating ceils (TNBC-T1Cs) exhibits similar aggressive phenotype to the human disease [ J ]. BMC Cancer, 2012, 12: 120.
  • 3Rakha EA, Putti TC, Abd E1-Rehim DM, et al. Morphological and immunophenotypic analysis of breast carcinomas with basal and myoepithelial differentiation [ J ]. J Pathol, 2006, 208 ( 4 ) : 495- 506.
  • 4Bonnet D, Dick JE. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell [ J ]. Nat Med, 1997, 3(7) : 730-737.
  • 5Fillmore C, Kuperwasser C. Human breast cancer cell lines contain stem-like ceils that self-renew, give rise to phenotypically diverse progeny and survive chemotherapy[ J]. Breast Cancer Res, 2008, 10(2) : R25.
  • 6Fillmore CM, Kuperwasser C. Human breast cancer cell lines contain stem-like ceils that self-renew, give rise to phenotypically diverse progeny and survive chemotherapy[ J]. Breast Cancer Res, 2008, 10(2) : R25.
  • 7Prud'homme GJ, Glinka Y, Toulina A, et al. Breast cancer stem- like cells are inhibited by a non-toxic aryl hydrocarbon receptor agonist [J]. PLoS One, 2010, 5(11): e13831.
  • 8Brenton JD, Carey LA, Ahmed AA, et al. Molecular classification and molecular forecasting of breast cancer: Ready for clinical application [ J ] ? J Clin Oncol, 2005,23 (29) :7350 - 7360.
  • 9Liu J, Lu KH, Liu Z1, et al. MicroRNA-100 is a potential molecular marker of non-small cell lung cancer and functions as a tumor suppressor by targeting polo-like kinase 1 [ J ]. BMC Cancer, 2012, 12: 519.
  • 10Hu K, Law JH, Fotovati A, et al. Small interfering RNA library screen identified polo-like kinase-1 (PLK1) as a potential therapeutic target for breast cancer that uniquely eliminates tumor- initiating ceils [ J]. Breast Cancer Res, 2012, 14 : R22.

引证文献5

二级引证文献25

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部