不同输注方法预防华蟾素所致静脉炎的效果观察

Prevention of Cinobufagin-induced phlebitis by using different infusion methods

目的观察不同输注方法对华蟾素致静脉炎发生率的影响。方法选取静脉滴注华蟾素注射液患者80例，随机分为观察组和对照组各40例，观察组在静脉滴注华蟾素注射液时，加入小剂量酚妥拉明，并在输注过程前、中、后输入少量生理盐水，对照组在静脉滴注华蟾素注射液时，只加入小剂量酚妥拉明。比较2组患者输液后静脉炎的发生率。结果观察组静脉炎的发生率为27．5％，对照组静脉炎的发生率为60．0％，二者比较差异显著。结论静脉滴注华蟾素注射液时，加入小剂量酚妥拉明，并在输注过程前、中、后输入少量生理盐水，能有效地预防华蟾素所致静脉炎的发生。

Objective To investigate the impact of different infusion methods on the incidence of Cinobufagin-induced phlebitis. Methods 80 patients required Cinobufagin infusion were enrolled and were randomized into the observation group and the control group with 40 patients in each group. In the observation group, low dose of phentolamine was added into the Cinobufagin solution. Normal saline was infused into patients before, during and after the course of the Cinobufagin infusion. For the control group, low dose of phentolamine was added into the Cinobufagin solution without normal saline infusion. The incidence of phlebitis was compared between two groups： Results The incidence of phlebitis in the observation group was 27.5%, and the control group was 60.0%. The difference was statistically signifi- cant. Conclusions Phlebitis induced by Cinobufagin-infusion can be prevented by addition of low dose of phentolamine and infusion of normal saline solution before, during and after the course of Cinobufagin infusion.