摘要
胃癌的发病率和病死率在我国各种恶性肿瘤中均居于首位，其早期诊断率低，患者预后差。CD133分子在胃癌组织的表达量显著高于癌旁正常组织，并与肿瘤大小、淋巴结转移及预后有关。同时，CD133阳性表达可能还与胃癌新生血管形成、浸润深度、分化程度及TNM分期具有相关性。本文旨在通过对CD133分子在胃癌组织中的特异性表达及其与胃癌发生发展和临床病理特征关系的进一步认识，以期为胃癌的早期诊断和靶向治疗带来新的研究方向。
The morbidity and mortality of gastric cancer stand in the first place among all kinds of malignant tumours in our country, the early diagnosis rate is still very low and the prognosis is unsatisfactory also. The expression of CD133 probably as a tumour stem cell marker is significantly higher in gastric cancer primary lesion than that in normal tissue and its higher expression corelates with the larger size of tumor, lymph node metastasis occurences and poorer prognosis. Meanwhile, the positive expression of CD133 may have some relationship with the angiogenesis, severer infiltration depth, worse differentiation degree and later TNM stage of gastric cancer. This paper aims at further recongnizing the specific expression of CD133 in gastric cancer primary lesion, both the relationship with initiating and clinical pathological features of gastric cancer, so as to bring a new research direction for early diagnosis and targeted therapy of stomach cancer.
出处
《国际外科学杂志》
2012年第1期56-59,共4页
International Journal of Surgery
