尼可地尔治疗冠心病慢性心力衰竭疗效观察

Clinical effect of Nicorandil in the treatment of heart failure caused by coronary heart disease

目的观察尼可地尔治疗冠心病慢性心力衰竭的临床疗效。方法选取在我院住院的冠心病慢性心力衰竭患者228例,随机分成实验组和对照组,对照组予常规治疗,实验组在对照组治疗方案的基础上加用尼可地尔治疗,以1个月为一个疗程,出院后随访观察5个月,观察治疗1个月后两组患者脑钠肽(BNP)值的变化以及随访5个月后左室射血分数(LVEF值)、室间隔厚度(IVS)、左室后壁厚度(LVP)、左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)的变化。结果实验组BNP值、IVS、LVP、LVEDD、LVESD值较对照组治疗后降低明显,LVEF值较对照组治疗后升高明显(P<0.05)。结论尼可地尔可以治疗冠心病慢性心力衰竭,改善患者症状的心功能。

Objective To observe the clinical effect of Nicorandil on heart failure caused by coronary heart disease.Methods 228 patients of heart failure caused by coronary heart disease were randomly divided into the study group（n=108） and the control group（n=120）.Patients in the control group were given conventional treatment,while those in the study group were given Nicorandil on the basis of conventional treatment.The variation of Brain Natriuretic Peptide（BNP） one month after treatment,and left ventricular ejection fraction（LVEF）,ventricular septal thickness（IVS）,left ventricular posterior wall thickness（LVP）,left ventricular end diastolic diameter（LVEDD） and left ventricular end systolic diameter（LVESD） five months after treatment were compared between the two groups.Results Compared with the control group,the decrease of BNP,IVS,LVP,LVEDD and LVESD in the study group after treatment was more significantly（P〈0.05）,and the increase of LVEF in the study group was more significantly（P〈0.05）.Conclusion Nicorandil can treat heart failure caused by coronary heart disease effectively and improve the cardiac function.