血清同型半胱氨酸水平与颈动脉粥样硬化的关系探讨

Relationship of serum homocysteine and carotid atherosclerosis

目的探讨血清同型半胱氨酸水平(Hcy)与颈动脉粥样硬化程度的关系。方法选择住院治疗的82例缺血性脑卒中患者,经彩色多普勒B超检查的结果分为颈动脉正常组、颈动脉内膜-中层增厚组、颈动脉粥样硬化斑块组,并测定血清同型半胱氨酸水平,进行组间比较。结果颈动脉粥样硬化斑块组的血清同型半胱氨酸水平明显高于颈动脉正常组及颈动脉内膜-中层增厚(IMT)组,差异有统计学意义(P<0.05);颈动脉内膜-中层增厚组与颈动脉正常组血清同型半胱氨酸水平比较,差异有统计学意义(P<0.05)。结论血清同型半胱氨酸水平高低与颈动脉粥样硬化程度呈正相关,血清同型半胱氨酸水平(Hcy)越高,颈动脉粥样硬化斑块、狭窄越严重。

Objective To study the relationship of serum homocysteine（Hcy） and carotid atherosclerosis.Methods 82 hospitalized cases with ischemic stroke by color Doppler ultrasound B,were divided into normal carotid artery,carotid artery intima-media thickening group,carotid artery atherosclerosis group,and serum homocysteine levels were examined and compared among three groups.Results Serum level of homocysteine（Hcy） group in carotid artery atherosclerosis group was significantly higher than that in the normal carotid artery and carotid artery intima-media thickening（IMT） group（P〈0.05）;serum levels of homocysteine（Hcy） in carotid artery intima-media thickening group was significantly higher than that in the normal carotid artery（P〈0.05）.Conclusion Serum homocysteine levels（Hcy） level and carotid artery atherosclerosis was positively related.The higher serum homocysteine（Hcy） levels is,the more severe stenosis the carotid atherosclerotic plaque is.