摘要
目的:分析大黄-黄连不同配伍比例合煎时大黄中蒽醌类成分的溶出变化。方法:水煎液经盐酸加热水解、三氯甲烷萃取等方法处理后,用RP-HPLC分析大黄单煎和配伍合煎液中5个蒽醌成分的溶出。结果:黄连-大黄5个配伍比例(1∶2～2∶1之间)中芦荟大黄素、大黄素、大黄酚、大黄素甲醚等4个蒽醌类成分有不同程度溶出增加,大黄酸有较大幅度的溶出降低。结论:在特定配伍比例范围内,配伍黄连对大黄中主要蒽醌成分有助溶作用。
Objective： To analyze dissolution changes of anthraquinones from Rheum tangaticum in different compatibility ratio of R.tangaticum and Coptis chinensis.Method： After decoction and hydrochloric acid were hydrolyzed by heating,CHCl3 extraction method and so on,RP-HPLC method was used to analysis dissolution of five anthraquinones from single-boiled of R.tangaticum and compatibility decoction.Result： In five combination ratios of R.tangaticum-C.chinensis（1∶2-2∶1）,dissolution of emodin,emodin,chrysophanol,and physcion had different degrees increased,dissolution of rhein decreased greatly.Conclusion： In range of specific compatibility ratio,compatibility with C.chinensis had solubilization effect for major anthraquinones from R.tangaticum.
出处
《中国实验方剂学杂志》
CAS
北大核心
2012年第3期1-4,共4页
Chinese Journal of Experimental Traditional Medical Formulae
基金
"重大新药创制"科技重大专项(2010ZX09401-406)
关键词
黄连
大黄
配伍
蒽醌
溶出变化
Coptis chinensis
Rheum tangaticum
compatibility
anthraquinone
dissolution changes
