中医药防治幽门螺杆菌相关性胃病的研究进展

Experimental Research Progress of Prevention and Cure in Helicobacter pylori-related Gastropathy by Traditional Chinese Medicine

查阅近几年国内外文献,对中医药抗幽门螺杆菌的实验研究相关文献进行整理并分析。检索万方医学数据库、中国知网(CNKI)和西文生物医学期刊数据库的38篇文献,将中药抗Heticobacter pylori的体外实验、体内实验的研究进展做一总结,并分析其机制。以往的研究从有效成分的筛选、抑菌浓度实验、抗菌机制研究和中医药对幽门螺杆菌感染动物模型的疗效研究,逐步扩展到细胞分子水平的观察。在今后的实验中还应紧密结合中医理论指导,合理选择中药和复方,规范动物模型制作和辨证分型,并严谨实验设计,才能更好的说明问题,以期为中医药防治幽门螺杆菌相关性胃病的更深入研究及临床应用奠定基础。

Review the domestic and foreign literature in recent years.Sort and analyze the literature about experimental researches of traditional Chinese medicine（TCM） on anti-Helicobacter pylori infection.By literatrue retrieval in Wan fang medical database,China Knowledge Resource Integrated Database,and Foreign Medical Journal Full-Text Service,we made a summary and analyze its mechanism in research progress of vivo and vitro experiments.From the active ingredient screening,inhibitory concentration experiments,anti-bacterial mechanism of traditional chinese medicine and efficacy study of animal models of H.pylori,gradually extended to the observation of cellular and molecular level in previous studies.Future experiments should combine with traditional Chinese medicine theory closely,select herbs and compound reasonably,make animal model and differentiate and type syndrome namatively,design experiments scrupulously,in order to illustrate better,and lay a foundation for the in-depth studies and clinical applications.