还元注射液对急性脑出血大鼠脑组织中乳酸、Ca^(2+)及自由基代谢的影响

Effect of Huanyuan Injection (HY) on the Metabolism of Lactic acid, Ca^(2+) and Free Radicals in Brain Tissue of Rats of Acute Cerebral Hemorrhage

以0.5μl胶原酶生理盐水从右侧内囊处注入制造大鼠脑出血模型,观察还元注射液对急性脑出血大鼠血肿周围区域脑组织乳酸、Ca^(2+)、超氧化物歧化酶(SOD)、丙二醛(MDA)等含量的影响,并与清开灵注射液作对照。结果表明模型对照组乳酸、Ca^(2+)、MDA等含量均明显高于正常对照组和手术对照组(P均<0.01),SOD活性明显低于正常对照组和手术对照组(P均<0.01);还元治疗组和清开灵对照组乳酸、Ca^(2+)、MDA等含量均显著低于模型对照组(P<0.05或P<0.01),SOD活性均显著高于模型对照组(P<0.05或P<0.01);在降低MDA含量方面。还元治疗组作用优于清开灵对照组(P<0.05)。

Cerebral hemorrhage model of rat was prepared by injecting 0. 5μl collagenase saline into its internal capsule and observation performed on the effect of HY on the contents of lactic acid. Ca2+. SOD. MDA in the hematoma area in the brain. Qingkailing (QKL) injection was used as control. Results revealed that the contents of lactic acid Ca2+. MDA in the model control group were obviously higher than that of the normal and operated control groups (P < 0. 01), activity of SOD markedly lowered than that the other 2 groups (P <. 0.01). The contents of lactic acid, Ca2+, MDA in the HY group were all obviously lowered than that of the model -control group (P < 0. 05 or P < 0. 01). activity of SOD markedly higher than that of the model - control group (P< 0. 05 or P<0. 01). The action of lowering the content of MDA of HY group was superior to the QKL control group (P < 0.05).